~SIMPLY BETTER PHARMACY~
501 Pharmacy, located at 69 Knox Way, Suite 110 in Chapel Hill, offers personalized pharmacy services including compounding and clinical care. Our friendly team provides expert guidance and free local delivery, while our cozy ice cream adds a sweet touch to your visit. We’re more than just a pharmacy—we’re your trusted healthcare partner and community hub.
Get Your Flu Shot Today — No Appointment Needed
Walk-ins accepted for patients 12 years and older.
What We Feature
Compounding
Prefer liquids over pills? Looking for an alternative to expensive creams?
Personal Service
Our independent pharmacy team can’t wait to get to know you and your family!
Local Delivery
Is your home or office located nearby? We’ll bring your prescription to you!
Let’s Get Started
Transfer Your Rx
We’re ready to fill your first order today and will make the process easy for you!
Have Questions?
No problem! Just give us a call at 984-999-0501 during business hours.
Local Delivery
Is your home or office located nearby? We’ll bring your prescription to you!
Thank You, Chapel Hill!
Thanks to everyone who voted for us in the 2024 and 2025 Best of Chapel Hill awards in Chapel Hill Magazine and for making us a Neighborhood Favorite on Nextdoor!
We Are Proud to Sponsor These Local Organizations
Here’s What Our Happy Customers Say…
Don’t just take our word for it, hear from our real 501 Pharmacy customers.
“Truly the best pharmacy in the Triangle region, as Han and his staff are wonderful. If you’re doing business with a big chain, I highly suggest you transfer your prescriptions to 501 Pharmacy.”
J. Ston
501 Pharmacy Customer“Han and staff have gone above and beyond anything you’ll find at other pharmacies. They see you as people with different needs and not just a prescription. They even help us with our pet prescriptions.”
Joanne A.
501 Pharmacy Customer“This pharmacy is a throwback to days gone by in the best possible way—a true neighborhood pharmacy where it feels like everybody knows you and they bend over backward to give prompt, excellent, and cheerful service. Great compounding and so much cheaper than similar pharmacies in Chapel Hill!”
Maqui O.
501 Pharmacy CustomerThe Blog
Join us on the 501 Pharmacy blog for behind-the-scenes stories from our team.
How to Dispose of Meds Without the “Pick and Peel” Struggle
We recently received a great question from a customer: “What is the easiest way to get labels off my bottles? Picking and peeling takes forever, and I have two shopping bags full of them!” We hear you. Life is too short to spend your afternoon fighting with adhesive. If you are looking to declutter your medicine cabinet and protect your privacy, we have a much faster way to handle your returns.
Continue Reading How to Dispose of Meds Without the “Pick and Peel” Struggle
The Drug Bug’s Guide to Allergy Season: Finding Your Path to Relief
The Drug Bug isn’t the only thing that’s going to be covered in pollen soon! As the North Carolina pines start dusting everything in yellow, millions of us are bracing for the familiar cycle of sneezing, itchy eyes, and congestion.
Continue Reading The Drug Bug’s Guide to Allergy Season: Finding Your Path to Relief
Help Us Make it 10: Running for Best of Chapel Hill, Again!
We’re honored to be nominated once again for Chapel Hill Magazine’s Best of Chapel Hill 2026—and this year is extra special. If we take the top spot, it will mark our 10th recognition!
Continue Reading Help Us Make it 10: Running for Best of Chapel Hill, Again!
